25663

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 419505..420004 Replicon chromosome
Accession NC_016052
Organism Tetragenococcus halophilus NBRC 12172

Toxin (Protein)


Gene name relE Uniprot ID A0A091C6L0
Locus tag TEH_RS01970 Protein ID WP_014123805.1
Coordinates 419735..420004 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A091CDY2
Locus tag TEH_RS01965 Protein ID WP_014123804.1
Coordinates 419505..419738 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TEH_RS01945 (TEH_04040) 414866..415129 + 264 WP_014123800.1 transposase -
TEH_RS01950 (TEH_04050) 415297..416727 - 1431 WP_014123801.1 IS5 family transposase -
TEH_RS01955 (TEH_04060) 417560..418525 + 966 WP_041591757.1 hypothetical protein -
TEH_RS01960 (TEH_04070) 418563..419315 + 753 Protein_390 acetamidase/formamidase family protein -
TEH_RS01965 (TEH_04080) 419505..419738 + 234 WP_014123804.1 hypothetical protein Antitoxin
TEH_RS01970 (TEH_04090) 419735..420004 + 270 WP_014123805.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
TEH_RS01975 (TEH_04100) 420437..420715 + 279 WP_014123806.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
TEH_RS01980 (TEH_04110) 421141..421542 - 402 WP_014123807.1 type II toxin-antitoxin system HicB family antitoxin -
TEH_RS01985 (TEH_04120) 421581..421772 - 192 WP_014123808.1 type II toxin-antitoxin system HicA family toxin -
TEH_RS01990 (TEH_04130) 421903..422964 + 1062 WP_014123809.1 acetamidase/formamidase family protein -
TEH_RS01995 (TEH_04140) 423126..423953 + 828 WP_014123810.1 hypothetical protein -
TEH_RS02000 (TEH_04150) 424022..424492 - 471 WP_014123811.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-70)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10511.30 Da        Isoelectric Point: 10.8418

>T25663 WP_014123805.1 NC_016052:419735-420004 [Tetragenococcus halophilus NBRC 12172]
MTFHVETTRRFDKQLKKLDKFAANTILKWLDKNIEGSNNPRLMGKPLVGNHSGKWRYRIGSYRVITKVDDEKLIILALEV
GHRKDIYRK

Download         Length: 270 bp

>T25663 NC_016052:419735-420004 [Tetragenococcus halophilus NBRC 12172]
ATGACTTTTCATGTAGAGACAACTCGTAGGTTCGATAAGCAATTAAAAAAATTAGACAAATTTGCTGCAAACACTATACT
TAAGTGGCTTGATAAAAATATTGAAGGAAGCAATAATCCAAGATTGATGGGTAAACCGCTCGTTGGAAATCACTCTGGGA
AATGGCGCTATCGAATAGGAAGTTATCGTGTGATTACCAAGGTTGACGACGAAAAATTAATTATTTTAGCTTTAGAAGTA
GGGCACAGGAAAGATATTTATAGAAAATAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8599.41 Da        Isoelectric Point: 3.8597

>AT25663 WP_014123804.1 NC_016052:419505-419738 [Tetragenococcus halophilus NBRC 12172]
MATITVRVTDEEKDFLDNMAKFEGKSLSELLKTTTLSSLEDAYDAQIGDAAYDEYLKNPQSRPLSESLEEYGLGESE

Download         Length: 234 bp

>AT25663 NC_016052:419505-419738 [Tetragenococcus halophilus NBRC 12172]
ATGGCTACTATTACTGTACGCGTTACTGATGAAGAAAAAGATTTTTTAGATAATATGGCAAAGTTTGAGGGAAAGAGTTT
GTCTGAACTATTAAAGACTACAACGCTGTCATCTTTAGAAGACGCCTATGATGCACAAATTGGGGATGCAGCTTATGATG
AGTATTTGAAAAATCCGCAATCCCGTCCTCTGTCAGAATCATTAGAGGAATACGGCTTAGGAGAGAGCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A091C6L0

Antitoxin

Source ID Structure
AlphaFold DB A0A091CDY2

References