256624

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2232881..2233403 Replicon chromosome
Accession NZ_CP103771
Organism Salmonella enterica strain S1905

Toxin (Protein)


Gene name stbE Uniprot ID V7IL40
Locus tag NYS49_RS10805 Protein ID WP_000221345.1
Coordinates 2232881..2233165 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag NYS49_RS10810 Protein ID WP_000885424.1
Coordinates 2233155..2233403 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYS49_RS10785 (2228956) 2228956..2230464 - 1509 WP_023138146.1 FAD-dependent oxidoreductase -
NYS49_RS10790 (2230509) 2230509..2230997 + 489 WP_023138147.1 MarR family winged helix-turn-helix transcriptional regulator -
NYS49_RS10795 (2231190) 2231190..2232263 + 1074 WP_023138148.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
NYS49_RS10800 (2232321) 2232321..2232710 - 390 WP_000194089.1 RidA family protein -
NYS49_RS10805 (2232881) 2232881..2233165 - 285 WP_000221345.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYS49_RS10810 (2233155) 2233155..2233403 - 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NYS49_RS10815 (2233816) 2233816..2234169 - 354 WP_000418733.1 hypothetical protein -
NYS49_RS10820 (2234172) 2234172..2234561 - 390 WP_001044696.1 hypothetical protein -
NYS49_RS10825 (2234926) 2234926..2235033 + 108 Protein_2111 IS110 family transposase -
NYS49_RS10830 (2235440) 2235440..2235772 + 333 WP_023138149.1 DUF1493 family protein -
NYS49_RS10835 (2236047) 2236047..2236235 - 189 WP_001276021.1 DUF29 family protein -
NYS49_RS10840 (2236648) 2236648..2237556 + 909 WP_023138150.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2230509..2240428 9919


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11043.79 Da        Isoelectric Point: 10.6500

>T256624 WP_000221345.1 NZ_CP103771:c2233165-2232881 [Salmonella enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT256624 WP_000885424.1 NZ_CP103771:c2233403-2233155 [Salmonella enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Y2FFA8

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References