Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1213533..1214153 Replicon chromosome
Accession NZ_CP103771
Organism Salmonella enterica strain S1905

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NYS49_RS05775 Protein ID WP_001280991.1
Coordinates 1213533..1213751 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag NYS49_RS05780 Protein ID WP_000344807.1
Coordinates 1213779..1214153 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYS49_RS05735 (1208757) 1208757..1209326 + 570 WP_000779802.1 YbaY family lipoprotein -
NYS49_RS05740 (1209359) 1209359..1209748 - 390 WP_000961285.1 MGMT family protein -
NYS49_RS05750 (1209979) 1209979..1211529 - 1551 WP_000213144.1 EAL domain-containing protein -
NYS49_RS05755 (1211754) 1211754..1212014 + 261 WP_000801421.1 type B 50S ribosomal protein L31 -
NYS49_RS05760 (1212020) 1212020..1212160 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
NYS49_RS05765 (1212215) 1212215..1212685 - 471 WP_000136183.1 YlaC family protein -
NYS49_RS05770 (1212803) 1212803..1213354 - 552 WP_001278793.1 maltose O-acetyltransferase -
NYS49_RS05775 (1213533) 1213533..1213751 - 219 WP_001280991.1 HHA domain-containing protein Toxin
NYS49_RS05780 (1213779) 1213779..1214153 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
NYS49_RS05785 (1214649) 1214649..1217798 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
NYS49_RS05790 (1217821) 1217821..1219014 - 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T256623 WP_001280991.1 NZ_CP103771:c1213751-1213533 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT256623 WP_000344807.1 NZ_CP103771:c1214153-1213779 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References