256619

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 442926..443442 Replicon chromosome
Accession NZ_CP103771
Organism Salmonella enterica strain S1905

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag NYS49_RS02115 Protein ID WP_000220578.1
Coordinates 443158..443442 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag NYS49_RS02110 Protein ID WP_000212724.1
Coordinates 442926..443168 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYS49_RS02090 (437946) 437946..439079 + 1134 WP_023138829.1 amidohydrolase/deacetylase family metallohydrolase -
NYS49_RS02095 (439063) 439063..440181 + 1119 WP_023138828.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
NYS49_RS02100 (440178) 440178..440918 + 741 WP_023138827.1 KDGP aldolase family protein -
NYS49_RS02105 (440935) 440935..442848 + 1914 WP_023203318.1 BglG family transcription antiterminator -
NYS49_RS02110 (442926) 442926..443168 + 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NYS49_RS02115 (443158) 443158..443442 + 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYS49_RS02120 (443446) 443446..443910 - 465 WP_017441190.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NYS49_RS02125 (444127) 444127..446265 - 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
NYS49_RS02130 (446674) 446674..448326 - 1653 WP_023138463.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T256619 WP_000220578.1 NZ_CP103771:443158-443442 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT256619 WP_000212724.1 NZ_CP103771:442926-443168 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References