256618

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1241209..1242126 Replicon chromosome
Accession NZ_CP103770
Organism Bacillus velezensis strain TH-1

Toxin (Protein)


Gene name spoIISA Uniprot ID I2HQ15
Locus tag NYO93_RS06495 Protein ID WP_007407256.1
Coordinates 1241380..1242126 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID I2HQ14
Locus tag NYO93_RS06490 Protein ID WP_003154807.1
Coordinates 1241209..1241379 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYO93_RS06450 (NYO93_06450) 1236442..1238064 + 1623 WP_032874601.1 pyocin knob domain-containing protein -
NYO93_RS06455 (NYO93_06455) 1238077..1238448 + 372 WP_032874603.1 XkdW family protein -
NYO93_RS06460 (NYO93_06460) 1238453..1238650 + 198 WP_032874605.1 XkdX family protein -
NYO93_RS06465 (NYO93_06465) 1238707..1239468 + 762 WP_032874607.1 hypothetical protein -
NYO93_RS06470 (NYO93_06470) 1239520..1239783 + 264 WP_003154815.1 hemolysin XhlA family protein -
NYO93_RS06475 (NYO93_06475) 1239797..1240060 + 264 WP_003154813.1 phage holin -
NYO93_RS06480 (NYO93_06480) 1240074..1240952 + 879 WP_032874609.1 N-acetylmuramoyl-L-alanine amidase -
NYO93_RS06485 (NYO93_06485) 1240987..1241112 - 126 WP_003154809.1 hypothetical protein -
NYO93_RS06490 (NYO93_06490) 1241209..1241379 - 171 WP_003154807.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
NYO93_RS06495 (NYO93_06495) 1241380..1242126 - 747 WP_007407256.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
NYO93_RS06500 (NYO93_06500) 1242231..1243229 - 999 WP_032874611.1 inorganic phosphate transporter -
NYO93_RS06505 (NYO93_06505) 1243242..1243859 - 618 WP_032874614.1 DUF47 domain-containing protein -
NYO93_RS06510 (NYO93_06510) 1244145..1245461 - 1317 WP_032874616.1 amino acid permease -
NYO93_RS06515 (NYO93_06515) 1245783..1246733 + 951 WP_032874618.1 ring-cleaving dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1197440..1299978 102538
- inside Prophage - - 1194256..1299978 105722


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29077.57 Da        Isoelectric Point: 4.7755

>T256618 WP_007407256.1 NZ_CP103770:c1242126-1241380 [Bacillus velezensis]
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVLGSMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYAEKMNVTASL
CDYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQNRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6676.74 Da        Isoelectric Point: 10.9273

>AT256618 WP_003154807.1 NZ_CP103770:c1241379-1241209 [Bacillus velezensis]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I2HQ15

Antitoxin

Source ID Structure
AlphaFold DB I2HQ14

References