Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3898462..3899279 Replicon chromosome
Accession NZ_CP103768
Organism Morganella morganii strain K266

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag NYO97_RS18810 Protein ID WP_015422406.1
Coordinates 3898462..3898968 (-) Length 169 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID J7TDK6
Locus tag NYO97_RS18815 Protein ID WP_004236533.1
Coordinates 3898971..3899279 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYO97_RS18770 (NYO97_18770) 3893821..3894444 - 624 WP_004236525.1 thiol:disulfide interchange protein DsbA -
NYO97_RS18775 (NYO97_18775) 3894463..3895458 - 996 WP_004236526.1 serine/threonine protein kinase -
NYO97_RS18780 (NYO97_18780) 3895458..3895727 - 270 WP_004240741.1 YihD family protein -
NYO97_RS18785 (NYO97_18785) 3895948..3896520 + 573 Protein_3648 molybdenum cofactor guanylyltransferase MobA -
NYO97_RS18790 (NYO97_18790) 3896527..3897045 + 519 WP_223302449.1 molybdopterin-guanine dinucleotide biosynthesis protein MobB -
NYO97_RS18795 (NYO97_18795) 3897260..3897562 + 303 WP_004240743.1 HdeA/HdeB family chaperone -
NYO97_RS18800 (NYO97_18800) 3897690..3898211 + 522 WP_015422407.1 isopentenyl-diphosphate Delta-isomerase -
NYO97_RS18805 (NYO97_18805) 3898208..3898348 + 141 WP_004236531.1 hypothetical protein -
NYO97_RS18810 (NYO97_18810) 3898462..3898968 - 507 WP_015422406.1 GNAT family N-acetyltransferase Toxin
NYO97_RS18815 (NYO97_18815) 3898971..3899279 - 309 WP_004236533.1 DUF1778 domain-containing protein Antitoxin
NYO97_RS18820 (NYO97_18820) 3899411..3900763 - 1353 WP_046024838.1 glutathione-disulfide reductase -
NYO97_RS18825 (NYO97_18825) 3900833..3901675 - 843 WP_259380451.1 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ -
NYO97_RS18830 (NYO97_18830) 3901865..3902254 + 390 WP_004236536.1 DUF1090 domain-containing protein -
NYO97_RS18835 (NYO97_18835) 3902666..3903658 + 993 WP_087825439.1 inner membrane protein YhjD -
NYO97_RS18840 (NYO97_18840) 3903766..3903972 + 207 WP_004236540.1 4-oxalocrotonate tautomerase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-143)

Antitoxin

Vibrio phage ICP1, Orf50

(21-94)


Sequences

Toxin        


Download         Length: 169 a.a.        Molecular weight: 18565.43 Da        Isoelectric Point: 9.9508

>T256614 WP_015422406.1 NZ_CP103768:c3898968-3898462 [Morganella morganii]
MNLTAPEPLQQHHDFTVFQSGEESLNHWLKTRALQNQQSGASRTFVVCHHNRIMAYYALSTGVITCSQAAGRFRRNMPPE
IPVILPGRLAVDESVKGRGIGRGLIKDAALRVLQAAGIVGIRGIVVRALSDNARRFYEHTGFMPSPADPMLLMITLRDLQ
LATGIYSE

Download         Length: 507 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11499.15 Da        Isoelectric Point: 8.6397

>AT256614 WP_004236533.1 NZ_CP103768:c3899279-3898971 [Morganella morganii]
MTKHTDEQHPVSGVNITRSTLNLRIKPEDKILIDRAAHAAGKNRTEFVLEAARRAAEETLADLRVIDVSTDVYQQFITRL
DMAPQSGEALKKTMLTKAPWEK

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB J7TDK6

References