Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1013502..1014128 Replicon chromosome
Accession NZ_CP103768
Organism Morganella morganii strain K266

Toxin (Protein)


Gene name Hha Uniprot ID A0A0A2RCL2
Locus tag NYO97_RS04790 Protein ID WP_024474604.1
Coordinates 1013502..1013705 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J7U1S9
Locus tag NYO97_RS04795 Protein ID WP_004236473.1
Coordinates 1013769..1014128 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYO97_RS04770 (NYO97_04770) 1010047..1010385 + 339 WP_004236467.1 P-II family nitrogen regulator -
NYO97_RS04775 (NYO97_04775) 1010405..1011694 + 1290 WP_064483483.1 ammonium transporter AmtB -
NYO97_RS04780 (NYO97_04780) 1011754..1012617 - 864 WP_032097922.1 acyl-CoA thioesterase II -
NYO97_RS04790 (NYO97_04790) 1013502..1013705 - 204 WP_024474604.1 HHA domain-containing protein Toxin
NYO97_RS04795 (NYO97_04795) 1013769..1014128 - 360 WP_004236473.1 Hha toxicity modulator TomB Antitoxin
NYO97_RS04800 (NYO97_04800) 1014691..1017867 - 3177 WP_015422956.1 efflux RND transporter permease subunit -
NYO97_RS04805 (NYO97_04805) 1017882..1019078 - 1197 WP_015422955.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-113)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8073.39 Da        Isoelectric Point: 6.9770

>T256613 WP_024474604.1 NZ_CP103768:c1013705-1013502 [Morganella morganii]
MTKLDYLMRLRKCTSIETLERVIEKNKYELTDDELEVFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13826.54 Da        Isoelectric Point: 4.2870

>AT256613 WP_004236473.1 NZ_CP103768:c1014128-1013769 [Morganella morganii]
MDEYSPRNYDIAVLKYLCDELCREGTQTLIRSNNYWVNDLASDSNLKLNELLGYIADVAWSFKIKHTQNKDLISFVDEYI
DETYALFGQMEVSFNDVEEWKKMASLVSSMLTSEGHLVH

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A2RCL2

Antitoxin

Source ID Structure
AlphaFold DB J7U1S9

References