Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 1..602 Replicon plasmid pMB9880_2
Accession NZ_CP103764
Organism Escherichia coli strain 5283

Toxin (Protein)


Gene name doc Uniprot ID U9YA20
Locus tag M5T11_RS25565 Protein ID WP_001216045.1
Coordinates 222..602 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag M5T11_RS25560 Protein ID WP_001190712.1
Coordinates 1..222 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T11_RS25560 (M5T11_25560) 1..222 + 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
M5T11_RS25565 (M5T11_25565) 222..602 + 381 WP_001216045.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
M5T11_RS25570 (M5T11_25570) 607..786 + 180 WP_000113018.1 hypothetical protein -
M5T11_RS25575 (M5T11_25575) 814..1857 + 1044 WP_029393260.1 DUF968 domain-containing protein -
M5T11_RS25580 (M5T11_25580) 1946..2398 + 453 WP_001326849.1 late promoter-activating protein -
M5T11_RS25585 (M5T11_25585) 2484..3677 + 1194 WP_060578234.1 hypothetical protein -
M5T11_RS25590 (M5T11_25590) 3677..5161 + 1485 WP_000124159.1 hypothetical protein -
M5T11_RS25595 (M5T11_25595) 5375..5476 + 102 Protein_7 transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..97212 97212


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13588.29 Da        Isoelectric Point: 5.1514

>T256611 WP_001216045.1 NZ_CP103764:222-602 [Escherichia coli]
MRHISPEELIALHDANISRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE

Download         Length: 381 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8133.10 Da        Isoelectric Point: 4.7708

>AT256611 WP_001190712.1 NZ_CP103764:1-222 [Escherichia coli]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CLP7

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References