Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4631452..4631949 Replicon chromosome
Accession NZ_CP103762
Organism Escherichia coli strain 5283

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag M5T11_RS22545 Protein ID WP_001173343.1
Coordinates 4631452..4631625 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag M5T11_RS22550 Protein ID WP_000398619.1
Coordinates 4631653..4631949 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T11_RS22535 (4628122) 4628122..4629579 + 1458 WP_000856827.1 dipeptide/tripeptide permease DtpC -
M5T11_RS22540 (4629816) 4629816..4631333 + 1518 WP_000003806.1 lysine--tRNA ligase -
M5T11_RS22545 (4631452) 4631452..4631625 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
M5T11_RS22550 (4631653) 4631653..4631949 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
M5T11_RS22555 (4632178) 4632178..4632450 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
M5T11_RS22560 (4632462) 4632462..4632692 - 231 WP_000373291.1 4Fe-4S mono-cluster protein YjdI -
M5T11_RS22565 (4632873) 4632873..4634504 + 1632 WP_001216477.1 sensor histidine kinase -
M5T11_RS22570 (4634501) 4634501..4635220 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T256603 WP_001173343.1 NZ_CP103762:c4631625-4631452 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT256603 WP_000398619.1 NZ_CP103762:c4631949-4631653 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References