Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4459007..4459602 Replicon chromosome
Accession NZ_CP103762
Organism Escherichia coli strain 5283

Toxin (Protein)


Gene name chpB Uniprot ID V0SXT4
Locus tag M5T11_RS21620 Protein ID WP_000239581.1
Coordinates 4459007..4459357 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag M5T11_RS21625 Protein ID WP_001223213.1
Coordinates 4459351..4459602 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T11_RS21600 (4454461) 4454461..4455483 - 1023 WP_001361374.1 ABC transporter permease -
M5T11_RS21605 (4455497) 4455497..4456999 - 1503 WP_001522399.1 sugar ABC transporter ATP-binding protein -
M5T11_RS21610 (4457132) 4457132..4458088 - 957 WP_001522398.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
M5T11_RS21615 (4458398) 4458398..4458928 + 531 WP_000055075.1 inorganic diphosphatase -
M5T11_RS21620 (4459007) 4459007..4459357 - 351 WP_000239581.1 endoribonuclease toxin ChpB Toxin
M5T11_RS21625 (4459351) 4459351..4459602 - 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
M5T11_RS21630 (4459814) 4459814..4460155 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
M5T11_RS21635 (4460158) 4460158..4463937 - 3780 WP_001522396.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12453.41 Da        Isoelectric Point: 6.2206

>T256601 WP_000239581.1 NZ_CP103762:c4459357-4459007 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT256601 WP_001223213.1 NZ_CP103762:c4459602-4459351 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SXT4

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References