Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/Txe-RelB
Location 125218..125725 Replicon chromosome
Accession NC_016050
Organism Rickettsia japonica YH

Toxin (Protein)


Gene name relB Uniprot ID G4KM08
Locus tag RJP_RS00680 Protein ID WP_014013837.1
Coordinates 125218..125481 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID G4KM09
Locus tag RJP_RS00685 Protein ID WP_014013838.1
Coordinates 125474..125725 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RJP_RS09290 120312..120431 + 120 WP_158309284.1 palindromic element RPE4 domain-containing protein -
RJP_RS00660 120719..121105 + 387 Protein_136 hypothetical protein -
RJP_RS08550 121184..121453 + 270 WP_096368100.1 hypothetical protein -
RJP_RS09295 121475..121651 + 177 WP_158309285.1 hypothetical protein -
RJP_RS00665 121755..123149 - 1395 WP_014120498.1 lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase -
RJP_RS00670 123146..123802 - 657 WP_014013835.1 lysophospholipid acyltransferase family protein -
RJP_RS00675 123953..125158 - 1206 WP_014120499.1 pyridoxal phosphate-dependent aminotransferase -
RJP_RS00680 125218..125481 - 264 WP_014013837.1 Txe/YoeB family addiction module toxin Toxin
RJP_RS00685 125474..125725 - 252 WP_014013838.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
RJP_RS00690 125865..126869 + 1005 WP_014120500.1 methyltransferase domain-containing protein -
RJP_RS00695 126874..127629 + 756 WP_024704441.1 VacJ family lipoprotein -
RJP_RS00700 127649..128248 + 600 WP_014120502.1 phospholipid-binding protein MlaC -
RJP_RS07370 128473..128760 + 288 WP_024704442.1 ribose-phosphate pyrophosphokinase-like domain-containing protein -
RJP_RS09695 128947..129336 + 390 WP_197535037.1 palindromic element RPE1 domain-containing protein -
RJP_RS00720 129481..130548 + 1068 WP_014120503.1 alanine racemase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10590.39 Da        Isoelectric Point: 9.8255

>T25660 WP_014013837.1 NC_016050:c125481-125218 [Rickettsia japonica YH]
MIEIEWTLEAAEDLVYWKKYDIKKYERIKLLIKNIQEASFTGIGKPEPLKHILSGLWSRRINHEHRLIYSVNTKQIIIYN
CRFHYKN

Download         Length: 264 bp

>T25660 NC_016050:c125481-125218 [Rickettsia japonica YH]
ATGATTGAGATTGAGTGGACACTAGAAGCAGCGGAGGATTTAGTGTATTGGAAAAAATACGATATTAAAAAATATGAACG
TATTAAACTTCTAATAAAAAATATCCAAGAAGCATCGTTTACAGGTATAGGTAAGCCCGAACCTTTAAAACATATATTAT
CAGGTTTATGGTCACGTAGAATTAACCACGAACATAGACTAATATATTCTGTCAATACTAAACAAATTATAATATATAAT
TGTAGATTTCATTATAAGAATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9537.81 Da        Isoelectric Point: 9.4884

>AT25660 WP_014013838.1 NC_016050:c125725-125474 [Rickettsia japonica YH]
MNSISGTSFRKNLSSVLNTVENDHVPYLIKRKNHKNIILLTEEEYESTKETLYLLSNLANANRIKKSIEQAKRGEFAKVN
LDD

Download         Length: 252 bp

>AT25660 NC_016050:c125725-125474 [Rickettsia japonica YH]
ATGAACTCAATTAGCGGCACTTCATTTAGAAAAAACTTAAGCTCTGTACTAAATACCGTAGAAAACGATCATGTCCCTTA
TCTTATTAAAAGAAAGAATCATAAGAATATTATTCTTTTAACCGAAGAAGAATATGAATCTACAAAAGAAACATTATATT
TATTATCTAATCTGGCTAATGCGAATCGAATAAAAAAATCTATCGAACAAGCAAAAAGAGGGGAGTTTGCTAAAGTTAAT
TTAGATGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F3RG12

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3RZ38

References