Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4341364..4342178 Replicon chromosome
Accession NZ_CP103762
Organism Escherichia coli strain 5283

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag M5T11_RS21010 Protein ID WP_001054376.1
Coordinates 4341364..4341621 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag M5T11_RS21015 Protein ID WP_001309181.1
Coordinates 4341633..4342178 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T11_RS20985 (4336652) 4336652..4337758 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
M5T11_RS20990 (4337823) 4337823..4338803 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
M5T11_RS20995 (4338913) 4338913..4339118 + 206 Protein_4108 HNH endonuclease -
M5T11_RS21000 (4339386) 4339386..4340626 - 1241 Protein_4109 helicase YjhR -
M5T11_RS21005 (4340742) 4340742..4340873 + 132 WP_001309182.1 hypothetical protein -
M5T11_RS21010 (4341364) 4341364..4341621 + 258 WP_001054376.1 YjhX family toxin Toxin
M5T11_RS21015 (4341633) 4341633..4342178 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
M5T11_RS21020 (4342234) 4342234..4342980 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
M5T11_RS21025 (4343149) 4343149..4343367 + 219 Protein_4114 hypothetical protein -
M5T11_RS21030 (4343405) 4343405..4343521 + 117 Protein_4115 VOC family protein -
M5T11_RS21035 (4343766) 4343766..4344887 + 1122 WP_000010829.1 M42 family metallopeptidase -
M5T11_RS21040 (4344884) 4344884..4345162 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
M5T11_RS21045 (4345174) 4345174..4346487 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimB 4333858..4350402 16544


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T256599 WP_001054376.1 NZ_CP103762:4341364-4341621 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT256599 WP_001309181.1 NZ_CP103762:4341633-4342178 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References