Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
| Location | 3933222..3934911 | Replicon | chromosome |
| Accession | NZ_CP103762 | ||
| Organism | Escherichia coli strain 5283 | ||
Toxin (Protein)
| Gene name | mosT | Uniprot ID | A0A829L165 |
| Locus tag | M5T11_RS19105 | Protein ID | WP_001521912.1 |
| Coordinates | 3933222..3934142 (-) | Length | 307 a.a. |
Antitoxin (Protein)
| Gene name | mosA | Uniprot ID | - |
| Locus tag | M5T11_RS19110 | Protein ID | WP_001521911.1 |
| Coordinates | 3934129..3934911 (-) | Length | 261 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M5T11_RS19090 (3929312) | 3929312..3930439 | - | 1128 | WP_001521913.1 | MFS transporter | - |
| M5T11_RS19095 (3930581) | 3930581..3931639 | - | 1059 | WP_122452191.1 | alpha/beta hydrolase | - |
| M5T11_RS19100 (3931904) | 3931904..3932788 | + | 885 | WP_001119037.1 | LysR family transcriptional regulator | - |
| M5T11_RS19105 (3933222) | 3933222..3934142 | - | 921 | WP_001521912.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| M5T11_RS19110 (3934129) | 3934129..3934911 | - | 783 | WP_001521911.1 | type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein | Antitoxin |
| M5T11_RS19115 (3935227) | 3935227..3938436 | + | 3210 | WP_001521910.1 | RNA-directed DNA polymerase | - |
| M5T11_RS19120 (3938783) | 3938783..3939253 | + | 471 | WP_000201185.1 | hypothetical protein | - |
| M5T11_RS19125 (3939250) | 3939250..3939352 | + | 103 | Protein_3745 | helix-turn-helix domain-containing protein | - |
| M5T11_RS19130 (3939444) | 3939444..3939602 | + | 159 | Protein_3746 | integrase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 307 a.a. Molecular weight: 34601.04 Da Isoelectric Point: 7.2649
>T256597 WP_001521912.1 NZ_CP103762:c3934142-3933222 [Escherichia coli]
MDLRDSYARQVKLLMAALPYVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLEKPGLMREIFDGFLCYLAGHPRPIAELLAPNWDTERITTLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHLTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAVLKDKNPAKYVAAVNKLERVLA
MDLRDSYARQVKLLMAALPYVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLEKPGLMREIFDGFLCYLAGHPRPIAELLAPNWDTERITTLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHLTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAVLKDKNPAKYVAAVNKLERVLA
Download Length: 921 bp
Antitoxin
Download Length: 261 a.a. Molecular weight: 29168.46 Da Isoelectric Point: 8.4458
>AT256597 WP_001521911.1 NZ_CP103762:c3934911-3934129 [Escherichia coli]
MPNYLNWLMQHTLPGQVLLQSWLTRNGIDRKLSYLYVKNGWLRRIAHGVYCRTGREPDWVDAVYCLQSQWEKPVRVAGLT
SLALQGHAHYTEQGKPQVWLALPAYVKLPGWFSAFEQSATFVTLYTSGLTADVTPFTTELKIGDRQLAGSVPELVAYEIA
CGVPSLISFEHADALFQGMNLLSPRKLQALLCASHSVKTNRVMLYLARRNGHPYFQFIDQSGIETGTGKRQIIPGGWLEP
DYQITVPRAFKPEGVEDGSA
MPNYLNWLMQHTLPGQVLLQSWLTRNGIDRKLSYLYVKNGWLRRIAHGVYCRTGREPDWVDAVYCLQSQWEKPVRVAGLT
SLALQGHAHYTEQGKPQVWLALPAYVKLPGWFSAFEQSATFVTLYTSGLTADVTPFTTELKIGDRQLAGSVPELVAYEIA
CGVPSLISFEHADALFQGMNLLSPRKLQALLCASHSVKTNRVMLYLARRNGHPYFQFIDQSGIETGTGKRQIIPGGWLEP
DYQITVPRAFKPEGVEDGSA
Download Length: 783 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|