Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3733441..3734059 Replicon chromosome
Accession NZ_CP103762
Organism Escherichia coli strain 5283

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag M5T11_RS18155 Protein ID WP_001291435.1
Coordinates 3733841..3734059 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag M5T11_RS18150 Protein ID WP_000344800.1
Coordinates 3733441..3733815 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T11_RS18140 (3728530) 3728530..3729723 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
M5T11_RS18145 (3729746) 3729746..3732895 + 3150 WP_001132480.1 efflux RND transporter permease AcrB -
M5T11_RS18150 (3733441) 3733441..3733815 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
M5T11_RS18155 (3733841) 3733841..3734059 + 219 WP_001291435.1 HHA domain-containing protein Toxin
M5T11_RS18160 (3734231) 3734231..3734782 + 552 WP_001522034.1 maltose O-acetyltransferase -
M5T11_RS18165 (3734898) 3734898..3735368 + 471 WP_001490888.1 YlaC family protein -
M5T11_RS18170 (3735532) 3735532..3737082 + 1551 WP_001577872.1 cyclic-guanylate-specific phosphodiesterase PdeB -
M5T11_RS18175 (3737124) 3737124..3737477 - 354 WP_000878140.1 DUF1428 domain-containing protein -
M5T11_RS18185 (3737856) 3737856..3738167 + 312 WP_000409911.1 MGMT family protein -
M5T11_RS18190 (3738198) 3738198..3738770 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T256596 WP_001291435.1 NZ_CP103762:3733841-3734059 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT256596 WP_000344800.1 NZ_CP103762:3733441-3733815 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References