Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3311754..3312459 Replicon chromosome
Accession NZ_CP103762
Organism Escherichia coli strain 5283

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag M5T11_RS16300 Protein ID WP_000539521.1
Coordinates 3311754..3312140 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag M5T11_RS16305 Protein ID WP_001280945.1
Coordinates 3312130..3312459 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T11_RS16280 (3307758) 3307758..3308384 + 627 WP_020233670.1 glutathione S-transferase GstB -
M5T11_RS16285 (3308381) 3308381..3309496 - 1116 WP_000555050.1 aldose sugar dehydrogenase YliI -
M5T11_RS16290 (3309607) 3309607..3309990 - 384 WP_000497137.1 biofilm formation regulator BssR -
M5T11_RS16295 (3310203) 3310203..3311528 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
M5T11_RS16300 (3311754) 3311754..3312140 + 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5T11_RS16305 (3312130) 3312130..3312459 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
M5T11_RS16310 (3312529) 3312529..3313857 - 1329 WP_000086873.1 GGDEF domain-containing protein -
M5T11_RS16315 (3313865) 3313865..3316213 - 2349 WP_021523051.1 EAL domain-containing protein -
M5T11_RS16320 (3316391) 3316391..3317302 - 912 WP_001236019.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T256595 WP_000539521.1 NZ_CP103762:3311754-3312140 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT256595 WP_001280945.1 NZ_CP103762:3312130-3312459 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References