Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3408495..3409113 Replicon chromosome
Accession NZ_CP103758
Organism Escherichia coli strain p10B

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NYO15_RS16675 Protein ID WP_001291435.1
Coordinates 3408895..3409113 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NYO15_RS16670 Protein ID WP_000344800.1
Coordinates 3408495..3408869 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYO15_RS16660 (3403584) 3403584..3404777 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NYO15_RS16665 (3404800) 3404800..3407949 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
NYO15_RS16670 (3408495) 3408495..3408869 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NYO15_RS16675 (3408895) 3408895..3409113 + 219 WP_001291435.1 HHA domain-containing protein Toxin
NYO15_RS16680 (3409285) 3409285..3409836 + 552 WP_000102536.1 maltose O-acetyltransferase -
NYO15_RS16685 (3409952) 3409952..3410422 + 471 WP_000136192.1 YlaC family protein -
NYO15_RS16690 (3410586) 3410586..3412136 + 1551 WP_044067661.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NYO15_RS16695 (3412178) 3412178..3412531 - 354 WP_000878140.1 DUF1428 domain-containing protein -
NYO15_RS16705 (3412910) 3412910..3413221 + 312 WP_000409911.1 MGMT family protein -
NYO15_RS16710 (3413252) 3413252..3413824 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T256570 WP_001291435.1 NZ_CP103758:3408895-3409113 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT256570 WP_000344800.1 NZ_CP103758:3408495-3408869 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References