Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 833409..834063 Replicon chromosome
Accession NZ_CP103758
Organism Escherichia coli strain p10B

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag NYO15_RS04075 Protein ID WP_000244777.1
Coordinates 833656..834063 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag NYO15_RS04070 Protein ID WP_000354046.1
Coordinates 833409..833675 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYO15_RS04045 (828578) 828578..829321 + 744 WP_000951964.1 SDR family oxidoreductase -
NYO15_RS04050 (829378) 829378..830811 - 1434 WP_001446971.1 6-phospho-beta-glucosidase BglA -
NYO15_RS04055 (830856) 830856..831167 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
NYO15_RS04060 (831331) 831331..831990 + 660 WP_000250274.1 hemolysin III family protein -
NYO15_RS04065 (832186) 832186..833166 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
NYO15_RS04070 (833409) 833409..833675 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
NYO15_RS04075 (833656) 833656..834063 + 408 WP_000244777.1 protein YgfX Toxin
NYO15_RS04080 (834103) 834103..834624 - 522 WP_001055874.1 flavodoxin FldB -
NYO15_RS04085 (834736) 834736..835632 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
NYO15_RS04090 (835657) 835657..836367 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NYO15_RS04095 (836373) 836373..838106 + 1734 WP_000813200.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T256561 WP_000244777.1 NZ_CP103758:833656-834063 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT256561 WP_000354046.1 NZ_CP103758:833409-833675 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References