Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4255052..4255572 Replicon chromosome
Accession NZ_CP103755
Organism Escherichia coli strain p11B

Toxin (Protein)


Gene name ccdB Uniprot ID A0A061KX66
Locus tag NYO14_RS21245 Protein ID WP_001160964.1
Coordinates 4255052..4255336 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V0VEX8
Locus tag NYO14_RS21250 Protein ID WP_000125566.1
Coordinates 4255339..4255572 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYO14_RS21220 (4250697) 4250697..4251983 + 1287 WP_000800457.1 peptidylprolyl isomerase SurA -
NYO14_RS21225 (4251983) 4251983..4252972 + 990 WP_000241227.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
NYO14_RS21230 (4252969) 4252969..4253790 + 822 WP_001065365.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
NYO14_RS21235 (4253793) 4253793..4254170 + 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
NYO14_RS21240 (4254177) 4254177..4255025 + 849 WP_000257181.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
NYO14_RS21245 (4255052) 4255052..4255336 - 285 WP_001160964.1 CcdB family protein Toxin
NYO14_RS21250 (4255339) 4255339..4255572 - 234 WP_000125566.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
NYO14_RS21255 (4255658) 4255658..4256137 - 480 WP_000624375.1 type 3 dihydrofolate reductase -
NYO14_RS21260 (4256329) 4256329..4258191 - 1863 WP_000377106.1 glutathione-regulated potassium-efflux system protein KefC -
NYO14_RS21265 (4258184) 4258184..4258714 - 531 WP_000600725.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
NYO14_RS21270 (4258822) 4258822..4260153 - 1332 WP_001183209.1 MFS transporter -
NYO14_RS21275 (4260212) 4260212..4260499 - 288 WP_000203744.1 ferredoxin-like protein FixX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-93)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10692.54 Da        Isoelectric Point: 10.3030

>T256541 WP_001160964.1 NZ_CP103755:c4255336-4255052 [Escherichia coli]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLIDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIK

Download         Length: 285 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8530.53 Da        Isoelectric Point: 5.8062

>AT256541 WP_000125566.1 NZ_CP103755:c4255572-4255339 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061KX66

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LTM9

References