Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3803452..3804070 Replicon chromosome
Accession NZ_CP103755
Organism Escherichia coli strain p11B

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NYO14_RS19090 Protein ID WP_001291435.1
Coordinates 3803852..3804070 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NYO14_RS19085 Protein ID WP_000344800.1
Coordinates 3803452..3803826 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYO14_RS19075 (3798541) 3798541..3799734 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NYO14_RS19080 (3799757) 3799757..3802906 + 3150 WP_001132478.1 efflux RND transporter permease AcrB -
NYO14_RS19085 (3803452) 3803452..3803826 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NYO14_RS19090 (3803852) 3803852..3804070 + 219 WP_001291435.1 HHA domain-containing protein Toxin
NYO14_RS19095 (3804244) 3804244..3804795 + 552 WP_000102539.1 maltose O-acetyltransferase -
NYO14_RS19100 (3804911) 3804911..3805381 + 471 WP_000136192.1 YlaC family protein -
NYO14_RS19105 (3805545) 3805545..3807095 + 1551 WP_001385227.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NYO14_RS19110 (3807137) 3807137..3807490 - 354 WP_000878135.1 DUF1428 family protein -
NYO14_RS19120 (3807869) 3807869..3808180 + 312 WP_000409908.1 MGMT family protein -
NYO14_RS19125 (3808211) 3808211..3808783 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T256539 WP_001291435.1 NZ_CP103755:3803852-3804070 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT256539 WP_000344800.1 NZ_CP103755:3803452-3803826 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References