Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 288940..289740 Replicon chromosome
Accession NZ_CP103755
Organism Escherichia coli strain p11B

Toxin (Protein)


Gene name ataT Uniprot ID F4T503
Locus tag NYO14_RS01340 Protein ID WP_000342452.1
Coordinates 289213..289740 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4T504
Locus tag NYO14_RS01335 Protein ID WP_001277107.1
Coordinates 288940..289206 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYO14_RS01315 (284599) 284599..285267 + 669 WP_000617723.1 cell division ATP-binding protein FtsE -
NYO14_RS01320 (285260) 285260..286318 + 1059 WP_001042013.1 permease-like cell division protein FtsX -
NYO14_RS01325 (286563) 286563..287417 + 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
NYO14_RS01330 (287688) 287688..288791 + 1104 WP_001021994.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
NYO14_RS01335 (288940) 288940..289206 + 267 WP_001277107.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
NYO14_RS01340 (289213) 289213..289740 + 528 WP_000342452.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
NYO14_RS01345 (289737) 289737..290120 - 384 WP_000778796.1 aspartate 1-decarboxylase autocleavage activator PanM -
NYO14_RS01350 (290543) 290543..291652 + 1110 WP_001296485.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
NYO14_RS01355 (291700) 291700..292626 + 927 WP_001295097.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
NYO14_RS01360 (292623) 292623..293900 + 1278 WP_000803819.1 branched chain amino acid ABC transporter permease LivM -
NYO14_RS01365 (293897) 293897..294664 + 768 WP_000082099.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19673.57 Da        Isoelectric Point: 6.6348

>T256526 WP_000342452.1 NZ_CP103755:289213-289740 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTPDD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9929.38 Da        Isoelectric Point: 10.0863

>AT256526 WP_001277107.1 NZ_CP103755:288940-289206 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILTEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061K5K9

Antitoxin

Source ID Structure
AlphaFold DB A0A061YQ57

References