Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4307084..4307679 Replicon chromosome
Accession NZ_CP103745
Organism Escherichia coli strain 3090

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag M5T02_RS20870 Protein ID WP_000239579.1
Coordinates 4307084..4307434 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag M5T02_RS20875 Protein ID WP_001223208.1
Coordinates 4307428..4307679 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T02_RS20850 (4302530) 4302530..4303552 - 1023 WP_001295197.1 ABC transporter permease -
M5T02_RS20855 (4303566) 4303566..4305068 - 1503 WP_000205784.1 sugar ABC transporter ATP-binding protein -
M5T02_RS20860 (4305208) 4305208..4306164 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
M5T02_RS20865 (4306474) 4306474..4307004 + 531 WP_000055072.1 inorganic diphosphatase -
M5T02_RS20870 (4307084) 4307084..4307434 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
M5T02_RS20875 (4307428) 4307428..4307679 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
M5T02_RS20880 (4307891) 4307891..4308232 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
M5T02_RS20885 (4308235) 4308235..4312014 - 3780 WP_000060978.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T256491 WP_000239579.1 NZ_CP103745:c4307434-4307084 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT256491 WP_001223208.1 NZ_CP103745:c4307679-4307428 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References