Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2890541..2891339 Replicon chromosome
Accession NZ_CP103745
Organism Escherichia coli strain 3090

Toxin (Protein)


Gene name yeeV Uniprot ID Q1RDD2
Locus tag M5T02_RS14025 Protein ID WP_001094434.1
Coordinates 2890541..2890915 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag M5T02_RS14030 Protein ID WP_001552747.1
Coordinates 2890962..2891339 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T02_RS13995 (2886323) 2886323..2886856 - 534 Protein_2740 DUF4942 domain-containing protein -
M5T02_RS14000 (2887050) 2887050..2888591 + 1542 WP_001298859.1 IS21-like element ISEc12 family transposase -
M5T02_RS14005 (2888606) 2888606..2889352 + 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -
M5T02_RS14010 (2889434) 2889434..2889751 - 318 Protein_2743 restriction endonuclease subunit M -
M5T02_RS14015 (2889844) 2889844..2890041 - 198 WP_000839257.1 DUF957 domain-containing protein -
M5T02_RS14020 (2890053) 2890053..2890544 - 492 WP_000976859.1 DUF5983 family protein -
M5T02_RS14025 (2890541) 2890541..2890915 - 375 WP_001094434.1 TA system toxin CbtA family protein Toxin
M5T02_RS14030 (2890962) 2890962..2891339 - 378 WP_001552747.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
M5T02_RS14035 (2891389) 2891389..2892033 - 645 WP_000086759.1 hypothetical protein -
M5T02_RS14040 (2892052) 2892052..2892273 - 222 WP_000692315.1 DUF987 domain-containing protein -
M5T02_RS14045 (2892336) 2892336..2892812 - 477 WP_001186774.1 RadC family protein -
M5T02_RS14050 (2892828) 2892828..2893301 - 474 WP_000855059.1 antirestriction protein -
M5T02_RS14055 (2893643) 2893643..2894461 - 819 WP_087523595.1 DUF932 domain-containing protein -
M5T02_RS14060 (2894579) 2894579..2894774 - 196 Protein_2753 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13921.82 Da        Isoelectric Point: 6.8517

>T256486 WP_001094434.1 NZ_CP103745:c2890915-2890541 [Escherichia coli]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAK

Download         Length: 375 bp

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13757.63 Da        Isoelectric Point: 6.3127

>AT256486 WP_001552747.1 NZ_CP103745:c2891339-2890962 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRTGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV

Download         Length: 378 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q1RDD2

Antitoxin

Source ID Structure

References