Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2465940..2466578 Replicon chromosome
Accession NZ_CP103745
Organism Escherichia coli strain 3090

Toxin (Protein)


Gene name hicA Uniprot ID A0A0A6TXU8
Locus tag M5T02_RS11800 Protein ID WP_001447010.1
Coordinates 2466402..2466578 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag M5T02_RS11795 Protein ID WP_001270286.1
Coordinates 2465940..2466356 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T02_RS11775 (2461092) 2461092..2462033 - 942 WP_001251304.1 ABC transporter permease -
M5T02_RS11780 (2462034) 2462034..2463047 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
M5T02_RS11785 (2463065) 2463065..2464210 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
M5T02_RS11790 (2464455) 2464455..2465861 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
M5T02_RS11795 (2465940) 2465940..2466356 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
M5T02_RS11800 (2466402) 2466402..2466578 - 177 WP_001447010.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
M5T02_RS11805 (2466800) 2466800..2467030 + 231 WP_000494244.1 YncJ family protein -
M5T02_RS11810 (2467122) 2467122..2469083 - 1962 WP_259429177.1 23S rRNA 5-hydroxycytidine C2501 synthase -
M5T02_RS11815 (2469156) 2469156..2469692 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
M5T02_RS11820 (2469784) 2469784..2470959 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6779.86 Da        Isoelectric Point: 11.2298

>T256485 WP_001447010.1 NZ_CP103745:c2466578-2466402 [Escherichia coli]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT256485 WP_001270286.1 NZ_CP103745:c2466356-2465940 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6TXU8

Antitoxin

Source ID Structure

References