Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4164127..4164928 Replicon chromosome
Accession NZ_CP103739
Organism Escherichia coli strain 3359

Toxin (Protein)


Gene name yeeV Uniprot ID U9ZA48
Locus tag M5T33_RS20530 Protein ID WP_001513431.1
Coordinates 4164551..4164928 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID U9YYT7
Locus tag M5T33_RS20525 Protein ID WP_001513429.1
Coordinates 4164127..4164504 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T33_RS20495 (4160958) 4160958..4161413 + 456 WP_000581502.1 IrmA family protein -
M5T33_RS20500 (4161556) 4161556..4161645 + 90 WP_112031555.1 DUF905 family protein -
M5T33_RS20505 (4161824) 4161824..4162642 + 819 WP_001513427.1 DUF932 domain-containing protein -
M5T33_RS20510 (4162697) 4162697..4163182 + 486 WP_001513428.1 antirestriction protein -
M5T33_RS20515 (4163198) 4163198..4163674 + 477 WP_001186726.1 RadC family protein -
M5T33_RS20520 (4163743) 4163743..4163964 + 222 WP_000692345.1 DUF987 domain-containing protein -
M5T33_RS20525 (4164127) 4164127..4164504 + 378 WP_001513429.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
M5T33_RS20530 (4164551) 4164551..4164928 + 378 WP_001513431.1 TA system toxin CbtA family protein Toxin
M5T33_RS20535 (4164925) 4164925..4165354 + 430 Protein_4001 DUF5983 family protein -
M5T33_RS20540 (4165366) 4165366..4165563 + 198 WP_001374283.1 DUF957 domain-containing protein -
M5T33_RS20545 (4165648) 4165648..4166490 + 843 WP_001513432.1 DUF4942 domain-containing protein -
M5T33_RS20550 (4166872) 4166872..4167003 + 132 Protein_4004 IS110 family transposase -
M5T33_RS20555 (4167813) 4167813..4168796 + 984 WP_001329577.1 KpsF/GutQ family sugar-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13941.80 Da        Isoelectric Point: 7.3225

>T256438 WP_001513431.1 NZ_CP103739:4164551-4164928 [Escherichia coli]
MNTLPDTHVREASGCPSPITIRQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPEAKQ

Download         Length: 378 bp

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13688.48 Da        Isoelectric Point: 5.9505

>AT256438 WP_001513429.1 NZ_CP103739:4164127-4164504 [Escherichia coli]
VSDTLPGTTPPDDNHDRPWWGLPCTVTSCFGARLVQEGNRLHYLADRAGIRGRFSDVDAYHLDQAFPLLMKQLELMLTGG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPATTV

Download         Length: 378 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9ZA48

Antitoxin

Source ID Structure
AlphaFold DB U9YYT7

References