Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2415510..2416148 Replicon chromosome
Accession NZ_CP103739
Organism Escherichia coli strain 3359

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag M5T33_RS11995 Protein ID WP_000813794.1
Coordinates 2415510..2415686 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag M5T33_RS12000 Protein ID WP_001270286.1
Coordinates 2415732..2416148 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T33_RS11975 (2411129) 2411129..2412304 - 1176 WP_001236251.1 BenE family transporter YdcO -
M5T33_RS11980 (2412396) 2412396..2412932 + 537 WP_000429133.1 DNA-binding transcriptional regulator SutR -
M5T33_RS11985 (2413005) 2413005..2414966 + 1962 WP_001301045.1 23S rRNA 5-hydroxycytidine C2501 synthase -
M5T33_RS11990 (2415058) 2415058..2415288 - 231 WP_000494244.1 YncJ family protein -
M5T33_RS11995 (2415510) 2415510..2415686 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
M5T33_RS12000 (2415732) 2415732..2416148 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
M5T33_RS12005 (2416227) 2416227..2417633 + 1407 WP_000760585.1 PLP-dependent aminotransferase family protein -
M5T33_RS12010 (2417878) 2417878..2419023 + 1146 WP_000047424.1 ABC transporter substrate-binding protein -
M5T33_RS12015 (2419041) 2419041..2420054 + 1014 WP_000220399.1 ABC transporter ATP-binding protein -
M5T33_RS12020 (2420055) 2420055..2420996 + 942 WP_001251313.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T256429 WP_000813794.1 NZ_CP103739:2415510-2415686 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT256429 WP_001270286.1 NZ_CP103739:2415732-2416148 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References