Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1332601..1333219 Replicon chromosome
Accession NZ_CP103739
Organism Escherichia coli strain 3359

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag M5T33_RS06510 Protein ID WP_001291435.1
Coordinates 1332601..1332819 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag M5T33_RS06515 Protein ID WP_000344800.1
Coordinates 1332845..1333219 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T33_RS06475 (1327891) 1327891..1328463 + 573 WP_000779831.1 YbaY family lipoprotein -
M5T33_RS06480 (1328494) 1328494..1328805 - 312 WP_000409911.1 MGMT family protein -
M5T33_RS06490 (1329184) 1329184..1329537 + 354 WP_000878140.1 DUF1428 domain-containing protein -
M5T33_RS06495 (1329579) 1329579..1331128 - 1550 Protein_1257 cyclic-guanylate-specific phosphodiesterase PdeB -
M5T33_RS06500 (1331292) 1331292..1331762 - 471 WP_000136192.1 YlaC family protein -
M5T33_RS06505 (1331878) 1331878..1332429 - 552 WP_000102564.1 maltose O-acetyltransferase -
M5T33_RS06510 (1332601) 1332601..1332819 - 219 WP_001291435.1 HHA domain-containing protein Toxin
M5T33_RS06515 (1332845) 1332845..1333219 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
M5T33_RS06520 (1333765) 1333765..1336914 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
M5T33_RS06525 (1336937) 1336937..1338130 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T256425 WP_001291435.1 NZ_CP103739:c1332819-1332601 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT256425 WP_000344800.1 NZ_CP103739:c1333219-1332845 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References