Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 629767..630362 Replicon chromosome
Accession NZ_CP103739
Organism Escherichia coli strain 3359

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag M5T33_RS03015 Protein ID WP_000239579.1
Coordinates 630012..630362 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag M5T33_RS03010 Protein ID WP_001223208.1
Coordinates 629767..630018 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T33_RS03000 (625432) 625432..629211 + 3780 WP_000060898.1 autotransporter assembly complex protein TamB -
M5T33_RS03005 (629214) 629214..629555 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
M5T33_RS03010 (629767) 629767..630018 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
M5T33_RS03015 (630012) 630012..630362 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
M5T33_RS03020 (630439) 630439..630969 - 531 WP_000055072.1 inorganic diphosphatase -
M5T33_RS03025 (631279) 631279..632235 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
M5T33_RS03030 (632376) 632376..633878 + 1503 WP_000210561.1 sugar ABC transporter ATP-binding protein -
M5T33_RS03035 (633892) 633892..634914 + 1023 WP_001353963.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T256421 WP_000239579.1 NZ_CP103739:630012-630362 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT256421 WP_001223208.1 NZ_CP103739:629767-630018 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References