Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/ElaA-DUF1778
Location 109972..110723 Replicon plasmid pMB2930_1
Accession NZ_CP103732
Organism Klebsiella pneumoniae strain 913

Toxin (Protein)


Gene name ataT Uniprot ID H6U1U8
Locus tag M5T23_RS27135 Protein ID WP_014386536.1
Coordinates 109972..110454 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A071LPN3
Locus tag M5T23_RS27140 Protein ID WP_004902250.1
Coordinates 110445..110723 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T23_RS27115 (M5T23_27115) 106371..107018 - 648 WP_014386537.1 EcsC family protein -
M5T23_RS27120 (M5T23_27120) 107045..107800 - 756 WP_004902235.1 DUF2971 domain-containing protein -
M5T23_RS27125 (M5T23_27125) 107901..108293 - 393 WP_032442757.1 hypothetical protein -
M5T23_RS27130 (M5T23_27130) 108398..108937 - 540 WP_004902239.1 hypothetical protein -
M5T23_RS27135 (M5T23_27135) 109972..110454 - 483 WP_014386536.1 GNAT family N-acetyltransferase Toxin
M5T23_RS27140 (M5T23_27140) 110445..110723 - 279 WP_004902250.1 DUF1778 domain-containing protein Antitoxin
M5T23_RS27145 (M5T23_27145) 110842..111054 - 213 WP_004902255.1 hypothetical protein -
M5T23_RS27150 (M5T23_27150) 111162..111502 - 341 Protein_121 hypothetical protein -
M5T23_RS27155 (M5T23_27155) 112332..112790 - 459 WP_014386535.1 hypothetical protein -
M5T23_RS27160 (M5T23_27160) 113443..113898 - 456 WP_001166628.1 Hg(II)-responsive transcriptional regulator -
M5T23_RS27165 (M5T23_27165) 113970..114335 + 366 WP_032430780.1 mercuric ion transporter MerT -
M5T23_RS27170 (M5T23_27170) 114351..114632 + 282 WP_000732277.1 mercury resistance system periplasmic binding protein MerP -
M5T23_RS27175 (M5T23_27175) 114660..115067 + 408 WP_000523860.1 organomercurial transporter MerC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid tet(A) / sul1 / qacE / ant(3'')-Ia / dfrA15 cheD 1..180461 180461


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(10-86)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17662.45 Da        Isoelectric Point: 8.9130

>T256419 WP_014386536.1 NZ_CP103732:c110454-109972 [Klebsiella pneumoniae]
MGMRAPESLTAEHNIAEFCCQEPALNEWLKKKALRNHSTGISRVYVVCAENTNRVIGYYCLSSGSVHRNTVPGAYRRNAP
DVIPVIVLGRLAIDQAWAGNGLGAALLKDAIYRTQNIAFQVGVRALAVHALNEEVKCFYTRFGFEPSIVNTLTLLFPIKV

Download         Length: 483 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10704.23 Da        Isoelectric Point: 4.5271

>AT256419 WP_004902250.1 NZ_CP103732:c110723-110445 [Klebsiella pneumoniae]
MKPDVREAPINIRAKTSQRDLIDMAASLVSKSRTDFMLEVACREAQDILLDQRLFLLNDNQFEAFIEELDAPITPERQAR
IDNLMNRKSPWE

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MBI1

Antitoxin

Source ID Structure
AlphaFold DB A0A071LPN3

References