Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 45883..46793 | Replicon | plasmid pMB2930_1 |
| Accession | NZ_CP103732 | ||
| Organism | Klebsiella pneumoniae strain 913 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | R4YBC5 |
| Locus tag | M5T23_RS26780 | Protein ID | WP_004144067.1 |
| Coordinates | 46323..46793 (+) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A6A8PHD0 |
| Locus tag | M5T23_RS26775 | Protein ID | WP_023287184.1 |
| Coordinates | 45883..46326 (+) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M5T23_RS26760 (M5T23_26760) | 41182..42363 | + | 1182 | WP_023287181.1 | hypothetical protein | - |
| M5T23_RS26765 (M5T23_26765) | 42360..44588 | + | 2229 | WP_032430744.1 | ThiF family adenylyltransferase | - |
| M5T23_RS26770 (M5T23_26770) | 44641..45782 | + | 1142 | Protein_45 | translesion error-prone DNA polymerase V subunit UmuC | - |
| M5T23_RS26775 (M5T23_26775) | 45883..46326 | + | 444 | WP_023287184.1 | DUF2384 domain-containing protein | Antitoxin |
| M5T23_RS26780 (M5T23_26780) | 46323..46793 | + | 471 | WP_004144067.1 | RES family NAD+ phosphorylase | Toxin |
| M5T23_RS26785 (M5T23_26785) | 46880..47875 | + | 996 | WP_192796503.1 | IS5 family transposase | - |
| M5T23_RS26790 (M5T23_26790) | 47877..48845 | + | 969 | WP_077253478.1 | IS5-like element IS903B family transposase | - |
| M5T23_RS26795 (M5T23_26795) | 49034..49294 | - | 261 | WP_017901409.1 | hypothetical protein | - |
| M5T23_RS26800 (M5T23_26800) | 49599..50567 | + | 969 | WP_074423483.1 | IS5 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | tet(A) / sul1 / qacE / ant(3'')-Ia / dfrA15 | cheD | 1..180461 | 180461 | |
| - | inside | IScluster/Tn | - | cheD | 46880..71259 | 24379 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17573.83 Da Isoelectric Point: 4.5152
>T256417 WP_004144067.1 NZ_CP103732:46323-46793 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPDNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPDNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
Antitoxin
Download Length: 148 a.a. Molecular weight: 16522.84 Da Isoelectric Point: 10.3013
>AT256417 WP_023287184.1 NZ_CP103732:45883-46326 [Klebsiella pneumoniae]
MKTFSLSSSPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSSPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A384IED8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6A8PHD0 |