Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4913754..4914270 Replicon chromosome
Accession NZ_CP103731
Organism Klebsiella pneumoniae strain 913

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag M5T23_RS23950 Protein ID WP_004178374.1
Coordinates 4913754..4914038 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag M5T23_RS23955 Protein ID WP_002886901.1
Coordinates 4914028..4914270 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T23_RS23925 (4909238) 4909238..4909501 - 264 WP_020324507.1 PTS system, lactose/cellobiose-specific IIB subunit -
M5T23_RS23930 (4909631) 4909631..4909804 + 174 WP_032408826.1 hypothetical protein -
M5T23_RS23935 (4909807) 4909807..4910550 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
M5T23_RS23940 (4910907) 4910907..4913045 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
M5T23_RS23945 (4913286) 4913286..4913750 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
M5T23_RS23950 (4913754) 4913754..4914038 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5T23_RS23955 (4914028) 4914028..4914270 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M5T23_RS23960 (4914348) 4914348..4916258 - 1911 WP_004178373.1 PRD domain-containing protein -
M5T23_RS23965 (4916281) 4916281..4917435 - 1155 WP_004178372.1 lactonase family protein -
M5T23_RS23970 (4917502) 4917502..4918242 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T256414 WP_004178374.1 NZ_CP103731:c4914038-4913754 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT256414 WP_002886901.1 NZ_CP103731:c4914270-4914028 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References