Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2762475..2764063 Replicon chromosome
Accession NZ_CP103731
Organism Klebsiella pneumoniae strain 913

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag M5T23_RS13560 Protein ID WP_004179815.1
Coordinates 2762475..2763797 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag M5T23_RS13565 Protein ID WP_004176198.1
Coordinates 2763797..2764063 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T23_RS13545 (2757531) 2757531..2760032 + 2502 WP_020323802.1 fimbria/pilus outer membrane usher protein -
M5T23_RS13550 (2760020) 2760020..2761024 + 1005 WP_004179822.1 fimbrial protein -
M5T23_RS13555 (2761166) 2761166..2762458 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
M5T23_RS13560 (2762475) 2762475..2763797 - 1323 WP_004179815.1 type II toxin-antitoxin system HipA family toxin Toxin
M5T23_RS13565 (2763797) 2763797..2764063 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
M5T23_RS13570 (2764329) 2764329..2764655 - 327 WP_002904788.1 hydroxyisourate hydrolase -
M5T23_RS13575 (2764652) 2764652..2765152 - 501 WP_004179811.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
M5T23_RS13580 (2765130) 2765130..2766509 - 1380 WP_004179808.1 nucleobase:cation symporter-2 family protein -
M5T23_RS13585 (2766855) 2766855..2768009 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
M5T23_RS13590 (2767990) 2767990..2768913 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - mgtC / iroE 2555290..2798898 243608


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49152.42 Da        Isoelectric Point: 7.2850

>T256409 WP_004179815.1 NZ_CP103731:c2763797-2762475 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTHQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT256409 WP_004176198.1 NZ_CP103731:c2764063-2763797 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References