Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 841062..841719 Replicon chromosome
Accession NZ_CP103731
Organism Klebsiella pneumoniae strain 913

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag M5T23_RS04145 Protein ID WP_002916310.1
Coordinates 841309..841719 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag M5T23_RS04140 Protein ID WP_002916312.1
Coordinates 841062..841328 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T23_RS04115 (836218) 836218..837651 - 1434 WP_004185559.1 6-phospho-beta-glucosidase BglA -
M5T23_RS04120 (837770) 837770..838498 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
M5T23_RS04125 (838548) 838548..838859 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
M5T23_RS04130 (839023) 839023..839682 + 660 WP_002916317.1 hemolysin III family protein -
M5T23_RS04135 (839833) 839833..840816 - 984 WP_020324927.1 tRNA-modifying protein YgfZ -
M5T23_RS04140 (841062) 841062..841328 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
M5T23_RS04145 (841309) 841309..841719 + 411 WP_002916310.1 protein YgfX Toxin
M5T23_RS04150 (841726) 841726..842247 - 522 WP_004144730.1 flavodoxin FldB -
M5T23_RS04155 (842348) 842348..843244 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
M5T23_RS04160 (843267) 843267..843980 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M5T23_RS04165 (843986) 843986..845719 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T256404 WP_002916310.1 NZ_CP103731:841309-841719 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT256404 WP_002916312.1 NZ_CP103731:841062-841328 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References