Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4718999..4719515 Replicon chromosome
Accession NZ_CP103729
Organism Klebsiella pneumoniae strain 197

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag M5R33_RS23320 Protein ID WP_040237797.1
Coordinates 4718999..4719283 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag M5R33_RS23325 Protein ID WP_002886901.1
Coordinates 4719273..4719515 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5R33_RS23295 (4714394) 4714394..4714657 - 264 WP_228938441.1 PTS sugar transporter subunit IIB -
M5R33_RS23300 (4714787) 4714787..4714960 + 174 WP_032408826.1 hypothetical protein -
M5R33_RS23305 (4714963) 4714963..4715706 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
M5R33_RS23310 (4716063) 4716063..4718201 + 2139 WP_040164650.1 anaerobic ribonucleoside-triphosphate reductase -
M5R33_RS23315 (4718531) 4718531..4718995 + 465 WP_004192393.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
M5R33_RS23320 (4718999) 4718999..4719283 - 285 WP_040237797.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5R33_RS23325 (4719273) 4719273..4719515 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M5R33_RS23330 (4719593) 4719593..4721503 - 1911 WP_009486549.1 PRD domain-containing protein -
M5R33_RS23335 (4721526) 4721526..4722680 - 1155 WP_004178372.1 lactonase family protein -
M5R33_RS23340 (4722747) 4722747..4723487 - 741 WP_004186692.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11067.91 Da        Isoelectric Point: 10.4962

>T256398 WP_040237797.1 NZ_CP103729:c4719283-4718999 [Klebsiella pneumoniae]
MTYELAFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT256398 WP_002886901.1 NZ_CP103729:c4719515-4719273 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References