Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2625457..2627045 Replicon chromosome
Accession NZ_CP103729
Organism Klebsiella pneumoniae strain 197

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag M5R33_RS13090 Protein ID WP_002904792.1
Coordinates 2625457..2626779 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag M5R33_RS13095 Protein ID WP_002904790.1
Coordinates 2626779..2627045 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5R33_RS13075 (2620513) 2620513..2623014 + 2502 WP_064150654.1 fimbria/pilus outer membrane usher protein -
M5R33_RS13080 (2623002) 2623002..2624006 + 1005 WP_114265827.1 fimbrial protein -
M5R33_RS13085 (2624148) 2624148..2625440 + 1293 WP_032423495.1 glycoside hydrolase family 10 protein -
M5R33_RS13090 (2625457) 2625457..2626779 - 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
M5R33_RS13095 (2626779) 2626779..2627045 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
M5R33_RS13100 (2627432) 2627432..2627758 - 327 WP_002904788.1 hydroxyisourate hydrolase -
M5R33_RS13105 (2627755) 2627755..2628255 - 501 WP_032446037.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
M5R33_RS13110 (2628233) 2628233..2629612 - 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
M5R33_RS13115 (2629958) 2629958..2631112 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
M5R33_RS13120 (2631093) 2631093..2632016 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T256395 WP_002904792.1 NZ_CP103729:c2626779-2625457 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT256395 WP_002904790.1 NZ_CP103729:c2627045-2626779 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References