Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 819709..820366 Replicon chromosome
Accession NZ_CP103729
Organism Klebsiella pneumoniae strain 197

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag M5R33_RS04145 Protein ID WP_002916310.1
Coordinates 819956..820366 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag M5R33_RS04140 Protein ID WP_002916312.1
Coordinates 819709..819975 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5R33_RS04115 (814865) 814865..816298 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
M5R33_RS04120 (816417) 816417..817145 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
M5R33_RS04125 (817195) 817195..817506 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
M5R33_RS04130 (817670) 817670..818329 + 660 WP_002916317.1 hemolysin III family protein -
M5R33_RS04135 (818480) 818480..819463 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
M5R33_RS04140 (819709) 819709..819975 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
M5R33_RS04145 (819956) 819956..820366 + 411 WP_002916310.1 protein YgfX Toxin
M5R33_RS04150 (820373) 820373..820894 - 522 WP_064150038.1 flavodoxin FldB -
M5R33_RS04155 (820995) 820995..821891 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
M5R33_RS04160 (821914) 821914..822627 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M5R33_RS04165 (822633) 822633..824366 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T256390 WP_002916310.1 NZ_CP103729:819956-820366 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT256390 WP_002916312.1 NZ_CP103729:819709-819975 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References