Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4606629..4607145 Replicon chromosome
Accession NZ_CP103727
Organism Klebsiella pneumoniae strain 2289

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag M5T50_RS22660 Protein ID WP_002886902.1
Coordinates 4606629..4606913 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag M5T50_RS22665 Protein ID WP_002886901.1
Coordinates 4606903..4607145 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T50_RS22635 (4602045) 4602045..4602308 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
M5T50_RS22640 (4602438) 4602438..4602611 + 174 WP_032410138.1 hypothetical protein -
M5T50_RS22645 (4602614) 4602614..4603357 + 744 WP_021441079.1 MurR/RpiR family transcriptional regulator -
M5T50_RS22650 (4603714) 4603714..4605852 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
M5T50_RS22655 (4606161) 4606161..4606625 + 465 WP_023302390.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
M5T50_RS22660 (4606629) 4606629..4606913 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5T50_RS22665 (4606903) 4606903..4607145 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M5T50_RS22670 (4607223) 4607223..4609133 - 1911 WP_009486549.1 PRD domain-containing protein -
M5T50_RS22675 (4609156) 4609156..4610310 - 1155 WP_023302389.1 lactonase family protein -
M5T50_RS22680 (4610377) 4610377..4611117 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T256383 WP_002886902.1 NZ_CP103727:c4606913-4606629 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT256383 WP_002886901.1 NZ_CP103727:c4607145-4606903 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References