Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 786062..786719 Replicon chromosome
Accession NZ_CP103727
Organism Klebsiella pneumoniae strain 2289

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag M5T50_RS03915 Protein ID WP_002916310.1
Coordinates 786309..786719 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag M5T50_RS03910 Protein ID WP_002916312.1
Coordinates 786062..786328 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T50_RS03885 (781218) 781218..782651 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
M5T50_RS03890 (782770) 782770..783498 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
M5T50_RS03895 (783548) 783548..783859 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
M5T50_RS03900 (784023) 784023..784682 + 660 WP_002916317.1 hemolysin III family protein -
M5T50_RS03905 (784833) 784833..785816 - 984 WP_004185555.1 tRNA-modifying protein YgfZ -
M5T50_RS03910 (786062) 786062..786328 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
M5T50_RS03915 (786309) 786309..786719 + 411 WP_002916310.1 protein YgfX Toxin
M5T50_RS03920 (786726) 786726..787247 - 522 WP_004144730.1 flavodoxin FldB -
M5T50_RS03925 (787348) 787348..788244 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
M5T50_RS03930 (788267) 788267..788980 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M5T50_RS03935 (788986) 788986..790719 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T256375 WP_002916310.1 NZ_CP103727:786309-786719 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT256375 WP_002916312.1 NZ_CP103727:786062-786328 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References