Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 4788335..4788951 Replicon chromosome
Accession NZ_CP103722
Organism Enterobacter hormaechei strain 3131

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag M5R19_RS22970 Protein ID WP_015569913.1
Coordinates 4788335..4788706 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6G4MTK3
Locus tag M5R19_RS22975 Protein ID WP_015569912.1
Coordinates 4788709..4788951 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5R19_RS22955 (M5R19_22955) 4785835..4786737 + 903 WP_014072386.1 formate dehydrogenase subunit beta -
M5R19_RS22960 (M5R19_22960) 4786734..4787369 + 636 WP_015569914.1 formate dehydrogenase cytochrome b556 subunit -
M5R19_RS22965 (M5R19_22965) 4787366..4788295 + 930 WP_003861956.1 formate dehydrogenase accessory protein FdhE -
M5R19_RS22970 (M5R19_22970) 4788335..4788706 - 372 WP_015569913.1 PIN domain-containing protein Toxin
M5R19_RS22975 (M5R19_22975) 4788709..4788951 - 243 WP_015569912.1 ribbon-helix-helix domain-containing protein Antitoxin
M5R19_RS22980 (M5R19_22980) 4789150..4790070 + 921 WP_015569911.1 alpha/beta hydrolase -
M5R19_RS22985 (M5R19_22985) 4790079..4791020 - 942 WP_015569910.1 fatty acid biosynthesis protein FabY -
M5R19_RS22990 (M5R19_22990) 4791065..4791502 - 438 WP_015569909.1 D-aminoacyl-tRNA deacylase -
M5R19_RS22995 (M5R19_22995) 4791499..4792380 - 882 WP_003861949.1 virulence factor BrkB family protein -
M5R19_RS23000 (M5R19_23000) 4792374..4792973 - 600 WP_003861947.1 glucose-1-phosphatase -
M5R19_RS23005 (M5R19_23005) 4793092..4793892 - 801 WP_003861944.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13767.90 Da        Isoelectric Point: 6.4882

>T256371 WP_015569913.1 NZ_CP103722:c4788706-4788335 [Enterobacter hormaechei]
MEHMAVFDTNILIDLFNNRIEAADAIEHTASHRAISLITWMEVMVSARRHGHEAKTAAVMGAFEIIDVSRDIAERSVLLR
EKHGMKLPDAIILATAQSRKCPLISRNTKDFAGIDEVLTPYQV

Download         Length: 372 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9440.72 Da        Isoelectric Point: 4.4076

>AT256371 WP_015569912.1 NZ_CP103722:c4788951-4788709 [Enterobacter hormaechei]
MSVLAELDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIELYLDQQSSSVIRNALGLWGDRKEDGLEYERKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6G4MTK3

References