Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3901653..3902310 Replicon chromosome
Accession NZ_CP103722
Organism Enterobacter hormaechei strain 3131

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag M5R19_RS18760 Protein ID WP_017382887.1
Coordinates 3901653..3902063 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag M5R19_RS18765 Protein ID WP_003863437.1
Coordinates 3902044..3902310 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5R19_RS18740 (M5R19_18740) 3897651..3899384 - 1734 WP_023304383.1 single-stranded-DNA-specific exonuclease RecJ -
M5R19_RS18745 (M5R19_18745) 3899390..3900103 - 714 WP_023295380.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M5R19_RS18750 (M5R19_18750) 3900132..3901028 - 897 WP_023304385.1 site-specific tyrosine recombinase XerD -
M5R19_RS18755 (M5R19_18755) 3901130..3901651 + 522 WP_015571793.1 flavodoxin FldB -
M5R19_RS18760 (M5R19_18760) 3901653..3902063 - 411 WP_017382887.1 protein YgfX Toxin
M5R19_RS18765 (M5R19_18765) 3902044..3902310 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
M5R19_RS18770 (M5R19_18770) 3902605..3903585 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
M5R19_RS18775 (M5R19_18775) 3903697..3904356 - 660 WP_003863433.1 hemolysin III family protein -
M5R19_RS18780 (M5R19_18780) 3904623..3905354 + 732 WP_015571796.1 MurR/RpiR family transcriptional regulator -
M5R19_RS18785 (M5R19_18785) 3905471..3906904 + 1434 WP_017382891.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T256370 WP_017382887.1 NZ_CP103722:c3902063-3901653 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT256370 WP_003863437.1 NZ_CP103722:c3902310-3902044 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References