Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-RHH
Location 4712602..4713218 Replicon chromosome
Accession NC_015968
Organism Enterobacter asburiae LF7a

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag ENTAS_RS22270 Protein ID WP_014072389.1
Coordinates 4712602..4712973 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A198H0E5
Locus tag ENTAS_RS22275 Protein ID WP_014072390.1
Coordinates 4712976..4713218 (-) Length 81 a.a.

Genomic Context

ENTAS_RS22255ENTAS_RS22260ENTAS_RS22265ENTAS_RS22280ENTAS_RS22270ENTAS_RS22275ENTAS_RS22285ENTAS_RS22290ENTAS_RS22295ENTAS_RS22300ENTAS_RS22305
Location: 4710102..4711004 (903 bp)
Type: Others
Protein ID: WP_014072386.1
Location: 4711001..4711636 (636 bp)
Type: Others
Protein ID: WP_014072387.1
Location: 4711633..4712562 (930 bp)
Type: Others
Protein ID: WP_014072388.1
Location: 4713418..4714335 (918 bp)
Type: Others
Protein ID: WP_014072391.1
Location: 4712602..4712973 (372 bp)
Type: Toxin
Protein ID: WP_014072389.1
Location: 4712976..4713218 (243 bp)
Type: Antitoxin
Protein ID: WP_014072390.1
Location: 4714352..4715293 (942 bp)
Type: Others
Protein ID: WP_041162159.1
Location: 4715338..4715775 (438 bp)
Type: Others
Protein ID: WP_014072393.1
Location: 4715772..4716653 (882 bp)
Type: Others
Protein ID: WP_014072394.1
Location: 4716647..4717246 (600 bp)
Type: Others
Protein ID: WP_014072395.1
Location: 4717377..4718165 (789 bp)
Type: Others
Protein ID: WP_014072396.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ENTAS_RS222554710102..4711004+903WP_014072386.1formate dehydrogenase subunit beta-
ENTAS_RS222604711001..4711636+636WP_014072387.1formate dehydrogenase cytochrome b556 subunit-
ENTAS_RS222654711633..4712562+930WP_014072388.1formate dehydrogenase accessory protein FdhE-
ENTAS_RS222704712602..4712973-372WP_014072389.1type II toxin-antitoxin system VapC family toxinToxin
ENTAS_RS222754712976..4713218-243WP_014072390.1ribbon-helix-helix protein, CopG familyAntitoxin
ENTAS_RS222804713418..4714335+918WP_014072391.1alpha/beta hydrolase-
ENTAS_RS222854714352..4715293-942WP_041162159.1fatty acid biosynthesis protein FabY-
ENTAS_RS222904715338..4715775-438WP_014072393.1D-tyrosyl-tRNA(Tyr) deacylase-
ENTAS_RS222954715772..4716653-882WP_014072394.1virulence factor BrkB family protein-
ENTAS_RS223004716647..4717246-600WP_014072395.1glucose-1-phosphatase-
ENTAS_RS223054717377..4718165-789WP_014072396.1DeoR/GlpR family DNA-binding transcription regulator-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-109)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13695.79 Da        Isoelectric Point: 6.9794

>T25637 WP_014072389.1 NC_015968:c4712973-4712602 [Enterobacter soli]
VEHMAVFDTNILIDLFNNRTEAANAIENTASRRAISLITWMEVMVGARRHGHEAKTAAVMRAFEIIDVSRDIAERSVLLR
EEHGMKLPDAIILATAQSRNCPLISRNTKDFAGIVGVISPYHL

Download         Length: 372 bp

>T25637 NC_015968:c4712973-4712602 [Enterobacter soli]
GTGGAACACATGGCCGTGTTTGATACCAACATTCTTATCGATCTCTTTAATAATCGCACTGAGGCAGCGAATGCGATTGA
AAACACAGCATCGCGCCGGGCGATCAGCCTGATTACCTGGATGGAAGTGATGGTCGGTGCGCGCAGGCACGGTCATGAAG
CAAAAACGGCGGCTGTGATGAGGGCTTTTGAGATTATCGATGTGTCGCGTGATATCGCGGAAAGAAGCGTTTTACTCCGT
GAGGAACACGGGATGAAACTGCCTGATGCCATCATTCTGGCCACAGCCCAGAGTAGAAATTGCCCATTGATTTCACGTAA
TACGAAAGATTTTGCGGGAATTGTTGGGGTTATCTCACCCTATCATCTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9468.69 Da        Isoelectric Point: 4.2463

>AT25637 WP_014072390.1 NC_015968:c4713218-4712976 [Enterobacter soli]
MSLLVNLDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIEQYLDQQSTSVIRDALGLWGNQQEDGLEYERKLREEW

Download         Length: 243 bp

>AT25637 NC_015968:c4713218-4712976 [Enterobacter soli]
ATGAGTCTTTTGGTGAACCTTGATATGGGCAGAATACTGATCGATTTGTCGGATGATGTCATTCAACGGCTGGATAACCT
CAAACAGCTGCGGAATCAACCTCGTGCCGAATTGCTGCGCGAAGCGATAGAACAGTATCTCGACCAGCAAAGCACTTCGG
TTATTCGTGATGCGCTGGGTCTGTGGGGGAACCAGCAAGAAGATGGGCTTGAGTACGAACGCAAGCTGCGTGAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A198H0E5

References