Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2427824..2428563 Replicon chromosome
Accession NZ_CP103722
Organism Enterobacter hormaechei strain 3131

Toxin (Protein)


Gene name tacT Uniprot ID A0A822W909
Locus tag M5R19_RS11665 Protein ID WP_017382345.1
Coordinates 2427824..2428309 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag M5R19_RS11670 Protein ID WP_003857131.1
Coordinates 2428297..2428563 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5R19_RS11645 (M5R19_11645) 2423240..2424601 - 1362 WP_000482601.1 FRG domain-containing protein -
M5R19_RS11650 (M5R19_11650) 2424615..2425418 - 804 WP_000589340.1 hypothetical protein -
M5R19_RS11655 (M5R19_11655) 2425477..2426823 - 1347 WP_076611902.1 ISNCY-like element ISLad2 family transposase -
M5R19_RS11660 (M5R19_11660) 2427204..2427773 + 570 WP_017382346.1 hypothetical protein -
M5R19_RS11665 (M5R19_11665) 2427824..2428309 - 486 WP_017382345.1 GNAT family N-acetyltransferase Toxin
M5R19_RS11670 (M5R19_11670) 2428297..2428563 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
M5R19_RS11675 (M5R19_11675) 2428627..2429537 - 911 Protein_2281 LysR family transcriptional regulator -
M5R19_RS11680 (M5R19_11680) 2429667..2431055 + 1389 WP_032619651.1 MFS transporter -
M5R19_RS11685 (M5R19_11685) 2431077..2432072 - 996 WP_023303746.1 DUF2891 domain-containing protein -
M5R19_RS11690 (M5R19_11690) 2432082..2433068 - 987 WP_017382341.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2425477..2426835 1358


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17510.21 Da        Isoelectric Point: 9.9658

>T256364 WP_017382345.1 NZ_CP103722:c2428309-2427824 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARAFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT256364 WP_003857131.1 NZ_CP103722:c2428563-2428297 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A822W909

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References