Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1272686..1273306 Replicon chromosome
Accession NZ_CP103722
Organism Enterobacter hormaechei strain 3131

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag M5R19_RS06195 Protein ID WP_015571250.1
Coordinates 1272686..1272904 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag M5R19_RS06200 Protein ID WP_006809850.1
Coordinates 1272932..1273306 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5R19_RS06165 (M5R19_06165) 1268698..1268958 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
M5R19_RS06170 (M5R19_06170) 1268961..1269101 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
M5R19_RS06175 (M5R19_06175) 1269098..1269808 - 711 WP_023303201.1 GNAT family protein -
M5R19_RS06180 (M5R19_06180) 1269910..1271370 + 1461 WP_032620143.1 PLP-dependent aminotransferase family protein -
M5R19_RS06185 (M5R19_06185) 1271342..1271809 - 468 WP_017383209.1 YlaC family protein -
M5R19_RS06190 (M5R19_06190) 1271926..1272477 - 552 WP_023303203.1 maltose O-acetyltransferase -
M5R19_RS06195 (M5R19_06195) 1272686..1272904 - 219 WP_015571250.1 HHA domain-containing protein Toxin
M5R19_RS06200 (M5R19_06200) 1272932..1273306 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
M5R19_RS06205 (M5R19_06205) 1273817..1276963 - 3147 WP_015571248.1 multidrug efflux RND transporter permease subunit AcrB -
M5R19_RS06210 (M5R19_06210) 1276986..1278179 - 1194 WP_017694395.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T256363 WP_015571250.1 NZ_CP103722:c1272904-1272686 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT256363 WP_006809850.1 NZ_CP103722:c1273306-1272932 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References