Detailed information of TA system TA025636

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3846019..3846676
• Replicon: chromosome
• Accession: NC_015968
• Organism: Enterobacter asburiae LF7a

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: ENTAS_RS18085
• Protein ID: WP_014071653.1
• Coordinates: 3846019..3846429 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A198H1V0
• Locus tag: ENTAS_RS18090
• Protein ID: WP_014071654.1
• Coordinates: 3846410..3846676 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ENTAS_RS18065	3842013..3843746	-	1734	WP_014071649.1	single-stranded-DNA-specific exonuclease RecJ	-
ENTAS_RS18070	3843752..3844465	-	714	WP_014071650.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
ENTAS_RS18075	3844494..3845390	-	897	WP_014071651.1	site-specific tyrosine recombinase XerD	-
ENTAS_RS18080	3845492..3846013	+	522	WP_014071652.1	flavodoxin FldB	-
ENTAS_RS18085	3846019..3846429	-	411	WP_014071653.1	protein YgfX	Toxin
ENTAS_RS18090	3846410..3846676	-	267	WP_014071654.1	FAD assembly factor SdhE	Antitoxin
ENTAS_RS18095	3846970..3847950	+	981	WP_014071655.1	tRNA-modifying protein YgfZ	-
ENTAS_RS18100	3848006..3848665	-	660	WP_014071656.1	hemolysin III family protein	-
ENTAS_RS18105	3848831..3849142	-	312	WP_014071658.1	N(4)-acetylcytidine aminohydrolase	-
ENTAS_RS18110	3849195..3849926	+	732	WP_014071659.1	MurR/RpiR family transcriptional regulator	-
ENTAS_RS18115	3850043..3851476	+	1434	WP_014071660.1	6-phospho-beta-glucosidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16191.12 Da
• Isoelectric Point: 11.5436

>T25636 WP_014071653.1 NC_015968:c3846429-3846019 [Enterobacter soli]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLMMDSRLRWQGK
EWEIIGTPWMLSSGMMLRLRKVGGGRRQHLWLAADSMDEVEWRDLRRMVLQQPTQE

Nucleotide

• Length: 411 bp

>T25636 NC_015968:c3846429-3846019 [Enterobacter soli]
GTGGTCCTGTGGCAATCTGATCTTCGCGTTTCATGGCGCTCGCAGTGGATGTCTTTATTGCTCCACGGCCTGGTCGCGGC
ATTTGTTTTACTGATGCCGTGGCCGCTTAGCTATACCCCTCTCTGGCTGCTGTTACTGTCATTCGTGGTGTTTGACAGCG
TGCGTAGTCAGCGCCGTATCAATGCCCGTCAGGGCGAAATCAAACTGATGATGGATTCACGCCTGCGCTGGCAGGGGAAA
GAGTGGGAAATTATCGGCACGCCATGGATGCTCAGTTCCGGCATGATGCTCAGGCTACGTAAGGTGGGCGGTGGGCGTCG
TCAGCACTTGTGGTTGGCAGCGGACAGTATGGATGAAGTGGAGTGGCGGGATCTGCGTCGGATGGTGTTGCAACAACCGA
CGCAGGAATAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10569.05 Da
• Isoelectric Point: 5.1456

>AT25636 WP_014071654.1 NC_015968:c3846676-3846410 [Enterobacter soli]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSEDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT25636 NC_015968:c3846676-3846410 [Enterobacter soli]
ATGGATATTAACAACAAGGCCCGTATCCACTGGGCTTGCCGTCGCGGAATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATACGAGTACGACAGCTTAAGCGAAGATGACAAGCGTCTGTTCGTTCGCCTGCTTGAATCCGACGATCCTGATT
TGTTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A198H1V0