Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4471477..4472072 Replicon chromosome
Accession NZ_CP103718
Organism Escherichia coli strain 1579

Toxin (Protein)


Gene name chpB Uniprot ID V0SXT4
Locus tag M5S87_RS21550 Protein ID WP_000239581.1
Coordinates 4471477..4471827 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag M5S87_RS21555 Protein ID WP_001223213.1
Coordinates 4471821..4472072 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S87_RS21530 (4466931) 4466931..4467953 - 1023 WP_001361374.1 ABC transporter permease -
M5S87_RS21535 (4467967) 4467967..4469469 - 1503 WP_001522399.1 sugar ABC transporter ATP-binding protein -
M5S87_RS21540 (4469602) 4469602..4470558 - 957 WP_001522398.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
M5S87_RS21545 (4470868) 4470868..4471398 + 531 WP_000055075.1 inorganic diphosphatase -
M5S87_RS21550 (4471477) 4471477..4471827 - 351 WP_000239581.1 endoribonuclease toxin ChpB Toxin
M5S87_RS21555 (4471821) 4471821..4472072 - 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
M5S87_RS21560 (4472284) 4472284..4472625 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
M5S87_RS21565 (4472628) 4472628..4476407 - 3780 WP_001522396.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12453.41 Da        Isoelectric Point: 6.2206

>T256343 WP_000239581.1 NZ_CP103718:c4471827-4471477 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT256343 WP_001223213.1 NZ_CP103718:c4472072-4471821 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SXT4

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References