Detailed information of TA system TA256339

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3949496..3951185
• Replicon: chromosome
• Accession: NZ_CP103718
• Organism: Escherichia coli strain 1579

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A829L165
• Locus tag: M5S87_RS19060
• Protein ID: WP_001521912.1
• Coordinates: 3949496..3950416 (-)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: M5S87_RS19065
• Protein ID: WP_001521911.1
• Coordinates: 3950403..3951185 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M5S87_RS19045 (3945586)	3945586..3946713	-	1128	WP_001521913.1	MFS transporter	-
M5S87_RS19050 (3946855)	3946855..3947913	-	1059	WP_122452191.1	alpha/beta hydrolase	-
M5S87_RS19055 (3948178)	3948178..3949062	+	885	WP_001119037.1	LysR family transcriptional regulator	-
M5S87_RS19060 (3949496)	3949496..3950416	-	921	WP_001521912.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
M5S87_RS19065 (3950403)	3950403..3951185	-	783	WP_001521911.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
M5S87_RS19070 (3951501)	3951501..3954710	+	3210	WP_001521910.1	RNA-directed DNA polymerase	-
M5S87_RS19075 (3955057)	3955057..3955527	+	471	WP_000201185.1	hypothetical protein	-
M5S87_RS19080 (3955524)	3955524..3955626	+	103	Protein_3736	helix-turn-helix domain-containing protein	-
M5S87_RS19085 (3955718)	3955718..3955876	+	159	Protein_3737	integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-261)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (95-247)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34601.04 Da
• Isoelectric Point: 7.2649

>T256339 WP_001521912.1 NZ_CP103718:c3950416-3949496 [Escherichia coli]
MDLRDSYARQVKLLMAALPYVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLEKPGLMREIFDGFLCYLAGHPRPIAELLAPNWDTERITTLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHLTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAVLKDKNPAKYVAAVNKLERVLA

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29168.46 Da
• Isoelectric Point: 8.4458

>AT256339 WP_001521911.1 NZ_CP103718:c3951185-3950403 [Escherichia coli]
MPNYLNWLMQHTLPGQVLLQSWLTRNGIDRKLSYLYVKNGWLRRIAHGVYCRTGREPDWVDAVYCLQSQWEKPVRVAGLT
SLALQGHAHYTEQGKPQVWLALPAYVKLPGWFSAFEQSATFVTLYTSGLTADVTPFTTELKIGDRQLAGSVPELVAYEIA
CGVPSLISFEHADALFQGMNLLSPRKLQALLCASHSVKTNRVMLYLARRNGHPYFQFIDQSGIETGTGKRQIIPGGWLEP
DYQITVPRAFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A829L165