Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3327954..3328659 Replicon chromosome
Accession NZ_CP103718
Organism Escherichia coli strain 1579

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag M5S87_RS16250 Protein ID WP_000539521.1
Coordinates 3327954..3328340 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag M5S87_RS16255 Protein ID WP_001280945.1
Coordinates 3328330..3328659 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S87_RS16230 (3323958) 3323958..3324584 + 627 WP_020233670.1 glutathione S-transferase GstB -
M5S87_RS16235 (3324581) 3324581..3325696 - 1116 WP_000555050.1 aldose sugar dehydrogenase YliI -
M5S87_RS16240 (3325807) 3325807..3326190 - 384 WP_000497137.1 biofilm formation regulator BssR -
M5S87_RS16245 (3326403) 3326403..3327728 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
M5S87_RS16250 (3327954) 3327954..3328340 + 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5S87_RS16255 (3328330) 3328330..3328659 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
M5S87_RS16260 (3328729) 3328729..3330057 - 1329 WP_000086873.1 GGDEF domain-containing protein -
M5S87_RS16265 (3330065) 3330065..3332413 - 2349 WP_021523051.1 EAL domain-containing protein -
M5S87_RS16270 (3332591) 3332591..3333502 - 912 WP_001236019.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T256337 WP_000539521.1 NZ_CP103718:3327954-3328340 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT256337 WP_001280945.1 NZ_CP103718:3328330-3328659 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References