Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4696388..4696904 Replicon chromosome
Accession NZ_CP103714
Organism Klebsiella pneumoniae strain ST15

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag M5T51_RS22725 Protein ID WP_004178374.1
Coordinates 4696388..4696672 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag M5T51_RS22730 Protein ID WP_002886901.1
Coordinates 4696662..4696904 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T51_RS22700 (4691872) 4691872..4692135 - 264 WP_020324507.1 PTS system, lactose/cellobiose-specific IIB subunit -
M5T51_RS22705 (4692265) 4692265..4692438 + 174 WP_032408826.1 hypothetical protein -
M5T51_RS22710 (4692441) 4692441..4693184 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
M5T51_RS22715 (4693541) 4693541..4695679 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
M5T51_RS22720 (4695920) 4695920..4696384 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
M5T51_RS22725 (4696388) 4696388..4696672 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5T51_RS22730 (4696662) 4696662..4696904 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M5T51_RS22735 (4696982) 4696982..4698892 - 1911 WP_004178373.1 PRD domain-containing protein -
M5T51_RS22740 (4698915) 4698915..4700069 - 1155 WP_004178372.1 lactonase family protein -
M5T51_RS22745 (4700136) 4700136..4700876 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T256314 WP_004178374.1 NZ_CP103714:c4696672-4696388 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT256314 WP_002886901.1 NZ_CP103714:c4696904-4696662 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References