Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2590983..2592571 Replicon chromosome
Accession NZ_CP103714
Organism Klebsiella pneumoniae strain ST15

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag M5T51_RS12650 Protein ID WP_004179815.1
Coordinates 2590983..2592305 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag M5T51_RS12655 Protein ID WP_004176198.1
Coordinates 2592305..2592571 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T51_RS12635 (2586039) 2586039..2588540 + 2502 WP_020323802.1 fimbria/pilus outer membrane usher protein -
M5T51_RS12640 (2588528) 2588528..2589532 + 1005 WP_004179822.1 fimbrial protein -
M5T51_RS12645 (2589674) 2589674..2590966 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
M5T51_RS12650 (2590983) 2590983..2592305 - 1323 WP_004179815.1 type II toxin-antitoxin system HipA family toxin Toxin
M5T51_RS12655 (2592305) 2592305..2592571 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
M5T51_RS12660 (2592837) 2592837..2593163 - 327 WP_002904788.1 hydroxyisourate hydrolase -
M5T51_RS12665 (2593160) 2593160..2593660 - 501 WP_004179811.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
M5T51_RS12670 (2593638) 2593638..2595017 - 1380 WP_004179808.1 nucleobase:cation symporter-2 family protein -
M5T51_RS12675 (2595363) 2595363..2596517 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
M5T51_RS12680 (2596498) 2596498..2597421 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49152.42 Da        Isoelectric Point: 7.2850

>T256310 WP_004179815.1 NZ_CP103714:c2592305-2590983 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTHQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT256310 WP_004176198.1 NZ_CP103714:c2592571-2592305 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References