Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 833891..834548 Replicon chromosome
Accession NZ_CP103714
Organism Klebsiella pneumoniae strain ST15

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag M5T51_RS04115 Protein ID WP_002916310.1
Coordinates 834138..834548 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag M5T51_RS04110 Protein ID WP_002916312.1
Coordinates 833891..834157 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T51_RS04085 (829047) 829047..830480 - 1434 WP_020324925.1 6-phospho-beta-glucosidase -
M5T51_RS04090 (830599) 830599..831327 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
M5T51_RS04095 (831377) 831377..831688 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
M5T51_RS04100 (831852) 831852..832511 + 660 WP_002916317.1 hemolysin III family protein -
M5T51_RS04105 (832662) 832662..833645 - 984 WP_020324927.1 tRNA-modifying protein YgfZ -
M5T51_RS04110 (833891) 833891..834157 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
M5T51_RS04115 (834138) 834138..834548 + 411 WP_002916310.1 protein YgfX Toxin
M5T51_RS04120 (834555) 834555..835076 - 522 WP_004144730.1 flavodoxin FldB -
M5T51_RS04125 (835177) 835177..836073 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
M5T51_RS04130 (836096) 836096..836809 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M5T51_RS04135 (836815) 836815..838548 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T256305 WP_002916310.1 NZ_CP103714:834138-834548 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT256305 WP_002916312.1 NZ_CP103714:833891-834157 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References