Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4227059..4227654 Replicon chromosome
Accession NZ_CP103704
Organism Escherichia coli strain ST361

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag M5T41_RS20530 Protein ID WP_000239579.1
Coordinates 4227059..4227409 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag M5T41_RS20535 Protein ID WP_001223208.1
Coordinates 4227403..4227654 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T41_RS20510 (4222508) 4222508..4223530 - 1023 WP_001353963.1 ABC transporter permease -
M5T41_RS20515 (4223544) 4223544..4225046 - 1503 WP_000210557.1 sugar ABC transporter ATP-binding protein -
M5T41_RS20520 (4225186) 4225186..4226142 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
M5T41_RS20525 (4226452) 4226452..4226982 + 531 WP_000055072.1 inorganic diphosphatase -
M5T41_RS20530 (4227059) 4227059..4227409 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
M5T41_RS20535 (4227403) 4227403..4227654 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
M5T41_RS20540 (4227866) 4227866..4228207 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
M5T41_RS20545 (4228210) 4228210..4231989 - 3780 WP_259419487.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T256265 WP_000239579.1 NZ_CP103704:c4227409-4227059 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT256265 WP_001223208.1 NZ_CP103704:c4227654-4227403 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References